TarunA

Tarun, Alice

Email: TarunA@alfredstate.edu
Department: Physical + Life Sciences
Office Location:Room 309 Physical and Health Sciences Bldg.
Office Phone: 607-587-3618

Education

1998  Ph.D. Comparative Biochemistry 

University of California, Berkeley, CA, USA

 

1986  B.S. Biology (Major: Genetics) Magna Cum Laude

University of the Philippines, Los Banos, Philippines, 


Teaching Overview

BIOL 1104 General Biology I

BIOL 2204 General Biology 2

BIOL 6534 Genetics

BIOL 2203 Human Biology

BIOL 4254 General Microbiology (Lab)


Professional Experience

2013-present Assistant Professor, Alfred State College, Alfred NY
2010 Certificate of Teaching Excellence, Graduate School of Public Health, University of Pittsburgh, Pittsburgh PA.
2009-2013 Assistant Professor, Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh PA
2004-2009 Research Scientist, Seattle Biomedical Research Institute, Seattle WA
2002-2004 Post-graduate Researcher, Department of Medicine, University of California, San Francisco CA
1998-2001 Post-graduate Researcher, Department of Plant and Microbial Biology, University of California, Berkeley CA


Research

PATENTS AND INVENTIONS

Tarun, A.S., Vaughan, A and Kappe, S.H.I. Inhibitors of fatty acid synthesis II as prophylactic agents against the liver stage of malaria. US and global patent application pending.

Duffy , P., Malkov , V.,  Tarun, A.S., Kappe, S.H.I., Krzych, U., Bergman, L., Wendle, J. Plasmodium Liver Stage Antigens. Patent no. WO 2007/041216.


Publications and Events

1. Tasdemir D, Sanabria D, Lauinger IL, Tarun A, Herman R, Perozzo R, Zloh M, Kappe SH, Brun R, Carballeira NM. 2010. 2-Hexadecynoic acid inhibits plasmodial FAS-II enzymes and arrests erythrocytic and liver stage Plasmodium infections. Bioorg Med Chem. 2010 Nov 1;18(21):7475-85. Epub 2010 Sep 18. PMID: 2085521
2. Pei Y, Tarun AS, Vaughan AM, Herman RW, Soliman JM, Erickson-Wayman A, Kappe SH. 2010. Plasmodium pyruvate dehydrogenase activity is only essential for the parasite's progression from liver infection to blood infection. Mol Microbiol. 2010 Feb;75(4):957-71. PMID: 20487290
3. Albuquerque SS, Carret C, Grosso AR, Tarun AS, Peng X, Kappe, SHI, Prudencio M and Mota MM. 2009. Host cell transcriptional profiling during malaria liver stage infection reveals a coordinated and sequential set of biological event. BMC Genomics 2009 Jun 17;10:270. PMID: 19534804
4. Tarun AS, Vaughan AM, Kappe SH. 2009. Redefining the role of de novo fatty acid synthesis in Plasmodium parasites.Trends Parasitol. Dec;25(12):545-50. Epub 2009 Oct 12. PMID: 19819758.
5. Kumar KA, Baxter P, Tarun AS, Kappe SH, Nussenzweig V. 2009. Conserved protective mechanisms in radiation and genetically attenuated uis3(-) and uis4(-) plasmodium sporozoites. PLoS ONE. 2009;4(2):e4480. Epub 2009 Feb 13. PMID: 19214236
6. Vaughan AM, O'Neill MT, Tarun AS, Camargo N, Phuong TM, Aly AS, Cowman AF, Kappe SH. 2008. Type II fatty acid synthesis is essential only for malaria parasite late liver stage development. Cellular Microbiology.11(3):506-20. Epub 2008 Dec 3. PMID:19068099.
7. Mikolajczak SA, Silva-Rivera H, Peng X, Tarun AS, Camargo N, Jacobs-Lorena V, Daly TM, Bergman LW, de la Vega P, Williams J, Aly AS, Kappe SH. 2008. Distinct malaria parasite sporozoites reveal transcriptional changes that cause differential tissue infection competence in the mosquito vector and mammalian host. Mol Cell Biol. 2008 Oct;28(20):6196-207. Epub 2008 Aug 18. PMID: 18710954.
8. Vaughan, A; S-Y Chiu; Gowthaman Ramasamy; Ling Li; Malcolm J. Gardner; A. S. Tarun; Stefan H.I. Kappe; Xinxia Peng. Assessment and improvement of the Plasmodium yoelii yoelii genome annotation through comparative analysis. 2008. Bioinformatics . 24: i383-i389. PMID: 18586738
9. Tarun, A. S., X. Peng, R. F. Dumpit, Y. Ogata, H. Silva-Rivera, N. Camargo, T.M. Daly, L.W. Bergman, and S.H. I. Kappe. 2008. A Combined Transcriptome and Proteome Survey of Malaria Parasite Liver Stages.” Proceedings of the National Academy of Sciences, USA. 105(1):305-10. PMID: 1817219*
*Cited with an F1000 rating of 6.0. Paul Roepe: Faculty of 1000 Biology, 10 Jan 2008 http://www.f1000biology.com/article/id/1098901/evaluation
10. Tarun, A. S., R. F. Dumpit, N. Camargo, M. Labaied, P. Liu, A. Takagi, R. Wang and S.H. I. Kappe. 2007. Protracted sterile protection with Plasmodium yoelii pre-erythrocytic genetically attenuated parasite malaria vaccines is independent of significant liver-stage persistence and is mediated by CD8+ Tcells. Journal of Infectious Diseases. 196(4):608-16. PMID: 17624848
11. Hua, S. S., Tarun, A. S., Pandey, S. N., Chang, L., Chang, P. K. 2007. Characterization of AFLAV, a Tf1/Sushi retrotransposon from Aspergillus flavus. Mycopathologia.163(2):97-104. PMID: 17286166
12. Tarun, A. S., K. Baer, R. F. Dumpit, S. Gray, N. Lejarcegui, U. Frevert and S. H. I. Kappe. 2006. Quantitative isolation and in vivo imaging of malaria parasite liver stages. International Journal of Parasitology. 36(12):1283-93. PMID: 16890231*
*Comment in S. Molloy. 2006. “Research Highlights: Malaria Hepatic Highlights”. Nature Reviews Microbiology. 4:719.
13. Shusterman, D., A. Tarun, M.A. Murphy and J. Morris. 2005. Seasonal allergic rhinitic and normal subjects respond differentially to nasal provocation with acetic acid vapor. Inhalation Toxicolology. 17(3):147-52. PMID: 15788375.
14. D. L. LeDuc*, Tarun A. S.*, M. Montes-Bayon, J. Meija, M. F. Malit, C.P. Wu, M. AbdelSamie, C.Y. Chiang, A. Tagmount, M. deSouza, B. Neuhierl, A. Bock, J. Caruso, and N. Terry. 2003. Overexpression of SeCys Methyltransferase in Arabidopsis thaliana and Brassica juncea Leads to Increased Selenite Resistance and Volatilization. 2004. Plant Physiology. 135(1):377-83. PMID: 14671009.
*authors contributed equally to this work
15. Tarun, A. S., B. Bryant, W. Zhai, C. Solomon, and D. Shusterman. 2003. Gene expression for carbonic anhydrase isoenzymes in human nasal mucosa. Chemical Senses. 28(7):621-9. PMID: 14578124.
16. Okubara, P. A., B. K. Tibbot, A. S. Tarun, C. E. McAlpin, and S. T. Hua. 2003. Partial retrotransposon-like DNA sequence in the genomic clone of Aspergillus flavus, pAF28. Mycological Research. 107: 841-6. PMID: 12967211.
17. Terry, N., A.M. Zayed, M.P. deSouza, and A.S. Tarun. 2000. Selenium in Higher Plants. Annual Review of Plant Physiology and Plant Molecular Biology., 51: 401-32. PMID: 15012198
18. Zhu, Y.L., E.A.H. Pilon-Smits, A. Tarun, S. U. Webber, L. Jouanin and N. Terry. 1999. Cadmium tolerance and accumulation in Indian mustard is enhanced by overexpressing glutamylcysteine synthetase. Plant Physiology, 1221: 1169-1177. PMID: 10594104.
19. Tarun, A.S., J. S. Lee and A. Theologis. 1998. Random mutagenesis of tomato 1-aminocyclopropane-1-carboxylate synthase: a key enzyme in ethylene biosynthesis. Proceedings of the National Academy of Sciences, USA. 95: 9796-9801. PMID: 9707555.
20. Tarun, A. S. 1998. ACC synthase Gene Expression and Biotechnology. In: L. Taiz and E. Zeiger (Editors). Plant Physiology. 2nd ed. Massachusetts: Sinnauer Assoc., Inc, p. 655.
21. Tarun, A. S. and A. Theologis. 1998. Complementation analysis of mutants of 1-aminocyclopropane-1-carboxylate synthase reveals the enzyme is a dimer with shared active sites. Journal of Biological Chemistry. 273: 12509-12514. PMID: 9575209.
22. Tarun, A.S. 1998. Structure-function analysis tomato 1-aminocyclopropane-1-carboxylate synthase: a key enzyme in ethylene biosynthesis. Ph.D. dissertation. University of California, Berkeley, CA. A. Theologis, adviser.


Honors and Awards

2003                ACHEMS Minority Travel Fellowship, Assoc. of Chemical Senses Society

1996                Outstanding Graduate Student Instructor, University of California,Berkeley

1995                Regents Fellowship, University of California, Berkeley

1989-1994       Rice Biotechnology Ph.D. Fellowship, Rockefeller Foundation

1986                Magna Cum Laude, University of the Philippines

1986                Outstanding Biology Senior, Phi Sigma Honor Society

1983-1986       University Scholar, University of the Philippines

1983-1986       Integrated Academic Program for the Sciences Scholarship, Department of Science and Technology, Philippines