This Internet-based course examines abnormal human physiology in a clinical context, with intent to develop specific intellectual skills related to nursing and other allied health professions. Pathophysiology is considered from a systemic perspective, with emphasis given to cellular abnormalities, disruptions of homeostasis, infectious disease, inflammation, and disorders of the blood, immune, cardiovascular, respiratory, digestive, endocrine, neurological, musculoskeletal, integumentary, renal, genitourinary, and reproductive systems. The course concludes with case study presentations to allow students to derive and discuss correlations among clinical healthcare or other related disciplinary settings.